Human iPSC-derived midbrain organoids functionally integrate into striatum circuits and restore motor function in a mouse model of Parkinson's disease
Xin Zheng, Deqiang Han, Weihua Liu, Xueyao Wang, Na Pan, Yuping Wang, Zhiguo Chen
Abstract
The findings of this study highlight the potential of hMOs as safe and efficacious donor graft sources for cell therapy to treat PD.
Topics & Concepts
Pars compactaSubstantia nigraNeuroscienceInduced pluripotent stem cellStriatumMidbrainDopaminergicBiologyStem cellOrganoidParkinson's diseaseCell biologyPathologyDopamineMedicineEmbryonic stem cellDiseaseCentral nervous systemBiochemistryGenePluripotent Stem Cells ResearchNerve injury and regenerationTissue Engineering and Regenerative Medicine