Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils
Camilla Margaroli, Diego Moncada Giraldo, Dalia Gulick, Brian Dobosh, Vincent D. Giacalone, Osric Forrest, Fangxu Sun, Chunhui Gu, Amit Gaggar, Haydn Kissick, Ronghu Wu, Greg Gibson, Rabindra Tirouvanziam
Abstract
. Broadly, our findings show that neutrophil plasticity is regulated at the site of inflammation via RNA and protein synthesis, leading to adaptations that affect their canonical functions (i.e., bacterial clearance).
Topics & Concepts
Cystic fibrosisAirwayMicrobiologyImmunologyMedicineChemistryBiologyInternal medicineAnesthesiaCystic Fibrosis Research AdvancesAntimicrobial Peptides and ActivitiesPneumonia and Respiratory Infections