Challenges and Breakthroughs in <i>Z</i>‐Enantioselective Olefin Metathesis
Jennifer Morvan, Antonio Del Vecchio, Jakub Talcik, Dylan Bouëtard, Marc Mauduit
Abstract
Abstract Asymmetric Olefin Metathesis (AOM) represents a highly versatile synthetic tool to lead to relevant chiral building blocks with excellent enantiopurity. As the Z ‐alkene moiety is ubiquitous in a wide range of natural products, the development of catalysts which are able to control both the Z ‐selectivity and the enantioselectivity of metathesis transformations is in high demands. This review aims to provide a comprehensive overview covering all the breakthroughs accomplished in the field of challenging Z ‐enantioselective olefin metathesis, which is of interest in the total synthesis of complex molecules.
Topics & Concepts
Enantioselective synthesisAlkeneMetathesisOlefin metathesisChemistryMoietyOlefin fiberCombinatorial chemistrySelectivitySalt metathesis reactionCatalysisOrganic chemistryStereochemistryPolymerizationPolymerSynthetic Organic Chemistry MethodsChemical Synthesis and AnalysisAsymmetric Synthesis and Catalysis