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USP18 enhances the resistance of BRAF-mutated melanoma cells to vemurafenib by stabilizing cGAS expression to induce cell autophagy

Zhou-rui Ma, Qianwei Xiong, Shizhong Cai, Lingtao Ding, Chao-hong Yin, Hongliang Xia, Wei Liu, Shu Guang Dai, Yue Zhang, Zhen-hong Zhu, Zhijian Huang, Qian Wang, Xiangming Yan

2023International Immunopharmacology14 citationsDOI

Topics & Concepts

VemurafenibMelanomaCancer researchAutophagyV600EBiologyGene knockdownMutantCell cultureApoptosisGeneBiochemistryGeneticsMetastatic melanomaUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyMelanoma and MAPK Pathways
USP18 enhances the resistance of BRAF-mutated melanoma cells to vemurafenib by stabilizing cGAS expression to induce cell autophagy | Litcius