Targeting DNA-PK overcomes acquired resistance to third-generation EGFR-TKI osimertinib in non-small-cell lung cancer
Xingmei Liang, Qiong Qin, Boning Liu, Xiaoqing Li, Lili Zeng, Jing Wang, Lingping Kong, Diansheng Zhong, Linlin Sun
Topics & Concepts
OsimertinibT790MCancer researchLung cancerDNA damageEpidermal growth factor receptorTyrosine kinaseDNA repairCisplatinMedicineBiologyChemistryCancerCell biologyDNASignal transductionOncologyInternal medicineGefitinibGeneticsErlotinibChemotherapyLung Cancer Treatments and MutationsCancer therapeutics and mechanismsQuinazolinone synthesis and applications