The aggregate-forming pili (AFP) mediates the aggregative adherence of a hybrid-pathogenic <i>Escherichia coli</i> (UPEC/EAEC) isolated from a urinary tract infection
Paulo Alfonso Schüroff, Fábia A. Salvador, Cecília M. Abe, Haleluya Wami, Enéas Carvalho, Rodrigo T. Hernandes, Ulrich Dobrindt, Tânia A. T. Gomes, Waldir P. Elias
Abstract
(encoding the AFP major pilin) led to the loss of pilin production and assembly, and notably, a strongly reduced adhesion to epithelial cells. In summary, the genetic background and phenotypic traits analyzed suggest that UPEC-46 is a hybrid strain (UPEC/EAEC) and highlights the importance of AFP adhesin in the adherence to colorectal and bladder cell lines.
Topics & Concepts
BiologyMicrobiologyPilusPilinEscherichia coliBacterial adhesinVirulenceFimbriaPlasmidEnteroaggregative Escherichia coliFimbriae ProteinsGenePathogenicity islandBiofilmEnterobacteriaceaeBacteriaGeneticsEscherichia coli research studiesEnterobacteriaceae and Cronobacter ResearchUrinary Tract Infections Management