Ursolic Acid Alleviates Mitotic Catastrophe in Podocyte by Inhibiting Autophagic P62 Accumulation in Diabetic Nephropathy
Hang Mei, Tienan Jing, H Liu, Yue Liu, Xinwang Zhu, Jiao Wang, Li Xu
Abstract
. Overall, our results provide strong evidence that UA could be a potential therapeutic agent for DN, regulated by inhibiting podocyte MC through the NF-κB/MDM2/Notch1 pathway by targeting autophagic-P62 accumulation.
Topics & Concepts
PodocyteAutophagyDiabetic nephropathyCell biologyCancer researchMitotic catastropheIn vivoChemistryProgrammed cell deathApoptosisBiologyKidneyEndocrinologyBiochemistryProteinuriaBiotechnologyAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismRenal Diseases and Glomerulopathies