QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene
Effrosyni Alexandrou, Dilek Guneri, Stephen Neidle, Zoë A. E. Waller
Abstract
. Here we show this ligand has strong opposing effects with i-motif DNA structures and is one of the most potent i-motif destabilising agents reported to date. QN-302 down-regulates the expression of numerous cancer-related genes by pan-quadruplex targeting. QN-302 exhibits exceptional combined synergistic effects compared to many other G-quadruplex and i-motif interacting compounds. This work further emphasises the importance of considering G-quadruplex and i-motif DNA structures as one dynamic system.
Topics & Concepts
ChemistryG-quadruplexMotif (music)PromoterDNAGeneMolecular biologyGeneticsComputational biologyGene expressionBiochemistryBiologyPhysicsAcousticsDNA and Nucleic Acid ChemistryRNA Interference and Gene DeliveryRNA and protein synthesis mechanisms