Anion effect on enantioselective oxidative NHC catalysis: highly efficient kinetic resolution of tertiary alcohols and beyond
Dan Hu, Si Bei Poh, Feipeng Liu, Zhifeng Tu, Xia Wang, Shenci Lu, Yu Zhao
Abstract
The effect of the counter-anion in the azolium pre-catalyst on enantio-control in oxidative NHC catalysis is demonstrated systematically for the first time in acylative kinetic resolution of oxindole-derived tertiary alcohols.
Topics & Concepts
Kinetic resolutionChemistryEnantioselective synthesisCatalysisOxindoleOxidative phosphorylationKinetic energyIonTertiary alcoholsCombinatorial chemistryOrganocatalysisOrganic chemistryMedicinal chemistryBiochemistryPhysicsQuantum mechanicsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods