Molecular docking and in vitro anticancer studies of silver(I)-N-heterocyclic carbene complexes
Mitat Akkoç, Siraj Khan, Hande Yüce, Neşe Başak Türkmen, Şeyma Yaşar, Sedat Yaşar, İsmaıl Özdemır
Abstract
are expected to be new lead compounds. In addition, molecular docking studies were performed to explore the binding interactions of silver complexes with the enzyme to explore new anticancer compounds. Furthermore, ADME properties of all complexes were predicted to explore lead-like characteristics and may be a potential drug candidate for cancer treatment.
Topics & Concepts
CytotoxicityChemistryADMECarbeneCell cultureStereochemistryIn vitroCisplatinDocking (animal)Cytotoxic T cellCancer cellEnzymeCombinatorial chemistryBiochemistryCancerBiologyGeneticsCatalysisChemotherapyNursingMedicineN-Heterocyclic Carbenes in Organic and Inorganic ChemistryQuinazolinone synthesis and applicationsCatalytic Cross-Coupling Reactions