Activation of FANCC attenuates mitochondrial ROS-driven necroptosis by targeting TBK1-dependent mitophagy in astrocytes after spinal cord injury
Mingjie Xia, Chaochen Li, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Hongxiang Hong, Jiawei Jiang, Guanhua Xu, Zhanyang Qian, Zhiming Cui
Abstract
The current study indicated that FANCC interacts with TBK1 and consequently mediates Parkin translocation, activates mitophagy, and inhibits astrocyte necroptosis. Our findings demonstrate the neuroprotective role and therapeutic potential of FANCC for SCI amelioration.
Topics & Concepts
MitophagyNecroptosisSpinal cord injuryMitochondrionAutophagyCell biologyAstrocyteSpinal cordProgrammed cell deathChemistryMedicineCancer researchBiologyNeuroscienceApoptosisCentral nervous systemBiochemistryAutophagy in Disease and TherapyMitochondrial Function and PathologyInfectious Encephalopathies and Encephalitis