<i>In situ</i> monitoring of functional activity of extracellular matrix stiffness-dependent multidrug resistance protein 1 using scanning electrochemical microscopy
Shuake Kuermanbayi, Yaowei Yang, Yuxiang Zhao, Yabei Li, Le Wang, Jin Yang, Yan Zhou, Feng Xu, Fei Li
Abstract
and quantitatively monitor the functional activity of MRP1 in cancer cells in different tumor mechanical microenvironments, which could help to elucidate the mechanism of matrix stiffness-dependent drug resistance behavior in cancer cells.
Topics & Concepts
Cancer cellExtracellular matrixChemistryBiophysicsCell biologyMaterials scienceCancerBiochemistryBiologyGeneticsElectrochemical Analysis and ApplicationsElectron and X-Ray Spectroscopy TechniquesAdvanced biosensing and bioanalysis techniques