Genome-Wide Identification of the LexA-Mediated DNA Damage Response in Streptomyces venezuelae
Kathryn J. Stratton, Matthew J. Bush, Govind Chandra, Clare E. M. Stevenson, Kim Findlay, Susan Schlimpert
Abstract
The transcriptional regulator LexA functions as a repressor of the bacterial SOS response, which is induced under DNA-damaging conditions. This results in the expression of genes important for survival and adaptation.
Topics & Concepts
Repressor lexABiologyRepressorSOS responseDNA damageGeneticsGeneDNAGenomeRegulatorRegulation of gene expressionGene expressionAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyMicrobial Natural Products and Biosynthesis