Multiple Faces of the Glioblastoma Microenvironment
Alina Simona Şovrea, Adina Bianca Boşca, Carmen Stanca Melincovici, Anne-Marie Constantin, Andreea Crintea, Mariana Viorica Mărginean, Eleonora Dronca, Elena Jianu, Rada Teodora Suflețel, Diana Gonciar, Maria Bungărdean, Carmen Crivii
Abstract
The tumor microenvironment is a highly dynamic accumulation of resident and infiltrating tumor cells, responsible for growth and invasion. The authors focused on the leading-edge concepts regarding the glioblastoma microenvironment. Due to the fact that the modern trend in the research and treatment of glioblastoma is represented by multiple approaches that target not only the primary tumor but also the neighboring tissue, the study of the microenvironment in the peritumoral tissue is an appealing direction for current and future therapies.