Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents
Anas Ramadan Kotb, Dina A. Bakhotmah, Abdallah E. Abdallah, Hazem Elkady, Mohammed S. Taghour, Ibrahim H. Eissa, Mohamed Ayman El‐Zahabi
Abstract
viability study against Vero non-cancerous cell line was investigated and the results reflected a high safety profile of all tested compounds. This work suggests 24b as a promising lead compound for development of new immunomodulatory anticancer agents.
Topics & Concepts
ThalidomideCombinatorial chemistryChemistryBiological activityComputational biologyPharmacologyBiochemistryBiologyIn vitroMultiple myelomaImmunologyMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsCancer therapeutics and mechanisms