Drugless peptide-based nanohybrids alleviate diabetic retinopathy by suppressing microglial activation and endothelial inflammation
Mei Du, Xiao Zhao, Miao Guo, Xiaoyu Wang, Yutian Zhang, Linshan Yang, Sixia Liu, Liya Sun, Mengyu Liao, Dong Xue, Yi Lei, Yumeng Zhao, Shuqi Liang, Xiaohong Wang, Caiyun You, Hong Yang, Hua Yan
Abstract
Our findings suggest that local injection of properly designed, drugless, peptide-based nanohybrids can serve as a safe and effective anti-inflammatory nanomedicine for treating DR.
Topics & Concepts
InflammationDiabetic retinopathyMicrogliaPeptideMedicineDiabetes mellitusCancer researchChemistryImmunologyEndocrinologyBiochemistryRetinal Diseases and TreatmentsRetinal Imaging and AnalysisAdvanced Glycation End Products research