Bioactive sulfonyl hydrazones with alkyl derivative: Characterization, ADME properties, molecular docking studies and investigation of inhibition on choline esterase enzymes for the diagnosis of Alzheimer's disease
Esra Bilen, Ümmühan Özdemir Özmen, Servet Çete, Sali̇ha Alyar, Ahmet Yaşar
Topics & Concepts
ADMEChemistryButyrylcholinesteraseLipinski's rule of fiveAcetylcholinesteraseSulfonylLipophilicityDocking (animal)StereochemistryEnzymeAlkylCombinatorial chemistryOrganic chemistryBiochemistryIn silicoIn vitroAchéNursingGeneMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity