Highly sensitive detection of paraquat with pillar[5]arenes as an aptamer in an α-hemolysin nanopore
Xiaojia Jiang, Mingsong Zang, Li Fei, Chunxi Hou, Quan Luo, Jiayun Xu, Junqiu Liu
Abstract
We report a highly sensitive biological nanopore sensor by introducing carboxylatopillar[5]arene (CP[5]A) molecule as an aptamer into the lumen of αHL nanopore for the single-molecule detection of paraquat (PQ) via host–guest interactions.
Topics & Concepts
NanoporeAptamerPillarParaquatNanotechnologyMoleculeMaterials scienceChemistryBiophysicsBiochemistryMolecular biologyBiologyOrganic chemistryEngineeringStructural engineeringNanopore and Nanochannel Transport StudiesLipid Membrane Structure and BehaviorMolecular Sensors and Ion Detection