Electrochemical detection of uric acid based on platinum nanoparticles/graphdiyne hybrids
Yanmin Zhang, Chen Ji, Xingtian Wang, Bin Qiu, Huaiyu Chen
Abstract
The development of cost-effective and high-performance electrochemical sensors for uric acid (UA) detection is critical due to its role as a key biomarker in disease diagnosis. This study presents an innovative sensor based on platinum nanoparticle (Pt NPs) decorated graphdiyne (GDY) nanohybrid (denoted as Pt NPs/GDY), fabricated via a facile electroless deposition method. The hybrid material capitalizes on the synergistic effects of GDY's π-electron-rich structure - enhancing target affinity through π-π stacking, and Pt NPs' dual functionality as conductivity boosters and catalytic activators. Electrochemical evaluations revealed that the Pt NPs/GDY-modified glassy carbon electrode (GCE) outperforms conventional GDY/GCE and bare GCE, achieving a broad linear range (0.1–7.5 μM) and an ultralow detection limit (30 nM). The sensor also demonstrated exceptional reproducibility, long-term stability, and selectivity against common interferents, validated by successful UA quantification in human urine samples (92.8–98.5 % recovery).