Strong sequence–dependence in RNA/DNA hybrid strand displacement kinetics
Francesca Smith, John Goertz, Križan Jurinović, Molly M. Stevens, Thomas E. Ouldridge
Abstract
Differences in DNA–DNA and hybrid RNA–DNA stability, parameterized by Δ G rd , leads to slopes in the free energy profile of hybrid strand displacement. These slopes are highly sequence-dependent, leading to strong sequence–dependence in reaction rates.
Topics & Concepts
KineticsSequence (biology)DNARNADisplacement (psychology)BiophysicsMaterials scienceBiologyGeneticsPhysicsGeneClassical mechanicsPsychologyPsychotherapistAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryBacteriophages and microbial interactions