A chemical inhibitor of heat shock protein 78 (HSP78) from Leishmania donovani represents a potential antileishmanial drug candidate
Sonali Das, Anindyajit Banerjee, Mohd Kamran, Sarfaraz Ahmad Ejazi, Mohammad Asad, Nahid Ali, Saikat Chakrabarti
Abstract
-di(adenosine-5')-pentaphosphate (Ap5A) ammonium salt as an LdHSP78 inhibitor. It selectively induced amastigote death at doses similar to amphotericin B doses, while exhibiting much less cytotoxicity to healthy macrophages than amphotericin B. In summary, using both a genetic knockout approach and pharmacological inhibition, we establish LdHSP78 as a drug target and Ap5A as a potential lead for improved antileishmanial agents.
Topics & Concepts
Leishmania donovaniAmastigoteBiologyLeishmaniaLeishmania mexicanaGene knockoutVisceral leishmaniasisHeat shock proteinLeishmaniasisPharmacologyImmunologyParasite hostingGeneBiochemistryWorld Wide WebComputer scienceResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsParasites and Host Interactions