Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma
Sarah E. Headland, Hart S. Dengler, Daqi Xu, Grace Teng, Christine Everett, Rojo A. Ratsimandresy, Donghong Yan, Jing Kang, Kirthana Ganeshan, Evgeniya V. Nazarova, Sarah Gierke, Christopher J. Wedeles, Riccardo Guidi, Daryle J. DePianto, Katrina B. Morshead, Alison Huynh, Jessica Mills, Sean Flanagan, Shannon Hambro, Víctor Núñez, Joanna E. Klementowicz, Yongchang Shi, Jianyong Wang, Jack Bevers, Vladimir Ramirez-Carrozzi, Rajita Pappu, Alex Abbas, Jason A. Vander Heiden, David F. Choy, Rajbharan Yadav, Zora Modrušan, Reynold A. Panettieri, Cynthia Koziol‐White, William F. Jester, Brendan J. Jenkins, Yi Cao, Christine Clarke, Cary D. Austin, Daniel Lafkas, Min Xu, Paul J. Wolters, Joseph R. Arron, Nathaniel R. West, Mark S. Wilson
Abstract
-deficient murine macrophages demonstrated that macrophage-derived OSM translates LPS signals into asthma-associated pathologies. Together, these data provide rationale for inhibiting OSM to prevent bacterial-associated progression and exacerbation of severe asthma.