Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFRL858R/T790M inhibitors
Jianheng Li, Baijiao An, Xianheng Song, Qianzhong Zhang, Chun Chen, Shuxian Wei, Run‐Zhu Fan, Xingshu Li, Yong Zou
Topics & Concepts
T790MChemistryPyrimidineEpidermal growth factor receptorTyrosine kinaseLung cancerIC50PharmacologyStructure–activity relationshipKinaseMoietyCancerCancer researchStereochemistryBiochemistryReceptorIn vitroGefitinibBiologyMedicineOncologyGeneticsLung Cancer Treatments and MutationsCancer therapeutics and mechanismsQuinazolinone synthesis and applications