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Entrectinib reverses cytostatic resistance through the inhibition of ABCB1 efflux transporter, but not the CYP3A4 drug-metabolizing enzyme

Dimitrios Vagiannis, Yu Zhang, Eva Novotná, A Morell, Jakub Hofman

2020Biochemical Pharmacology19 citationsDOI

Topics & Concepts

PharmacologyCYP3A4EffluxDrug resistanceAbcg2BiologyATP-binding cassette transporterChemistryTransporterCytochrome P450EnzymeBiochemistryGeneGeneticsDrug Transport and Resistance MechanismsCancer therapeutics and mechanismsLung Cancer Treatments and Mutations
Entrectinib reverses cytostatic resistance through the inhibition of ABCB1 efflux transporter, but not the CYP3A4 drug-metabolizing enzyme | Litcius