<i>Leuconostoc pseudomesenteroides</i> improves microbiota dysbiosis and liver metabolism imbalance and ameliorates the correlation between dihydroceramide and strains of Firmicutes and Proteobacteria in high fat diet obese mice
Mengzhen Sun, Qiya Wang, Maomao Zhang, Maomao Zhang, Guohua Zhang, Tao Wu, Rui Liu, Wenjie Sui, Jiaojiao Zhang, Jinjin Yin, Min Zhang, Min Zhang
Abstract
CFU per day per mouse effectively attenuated the weight of mice, significantly reduced serum lipids, and markedly improved fecal lipid output. Tu also ameliorated the lipid profiles in the liver and epididymal fat tissues, and restored intestinal disorder caused by a high-fat diet. Moreover, glycerophospholipid metabolism in the liver was altered by increased dihydroceramide levels. Surprisingly, the correlation between dihydroceramide and strains of Firmicutes and Proteobacteria was found for the first time. Collectively, these findings highlight that Tu could be a potential dietary supplement for weight control.