Delivery of siRNA based on engineered exosomes for glioblastoma therapy by targeting STAT3
Shifu Liang, Fangfang Zuo, Bin‐Cheng Yin, Bang‐Ce Ye
Abstract
anti-GBM therapeutic effects due to the exosomes for siRNA protection and An2 modification for GBM targeting and BBB penetration. Such superior properties of Exo-An2-siRNA are responsible for favorable inhibition of the proliferation of orthotopic U87MG xenografts with limited side effects, significantly enhancing the median survival time (MST) of U87MG-bearing nude mice. The developed siRNA therapy featuring An2-functionalized exosomes as nanoplatforms is a safe and effective GBM treatment strategy.
Topics & Concepts
Small interfering RNAMicrovesiclesCancer researchBlood–brain barrierImmunogenicityRNA interferencemicroRNAGlioblastomaIn vitroSTAT3ExosomeChemistryBiologyCell biologyMedicineRNASignal transductionImmunologyImmune systemGeneCentral nervous systemNeuroscienceBiochemistryExtracellular vesicles in diseaseMicroRNA in disease regulationRNA Interference and Gene Delivery