Development of lacto-series ganglioside fluorescent probe using late-stage sialylation and behavior analysis with single-molecule imaging
Maina Takahashi, Naoko Komura, Yukako Yoshida, Eriko Yamaguchi, Ami Hasegawa, Hidenori Tanaka, Akihiro Imamura, Hideharu Ishida, Kenichi Suzuki, Hiromune Ando
Abstract
interactions between the lacto-series ganglioside and a major raft molecule (GPI-anchored protein CD59). Moreover, the fluorescent non-sialylated (asialyl) lactotetraosylceramide behaved similarly to its sialyl counterpart.
Topics & Concepts
GangliosideGlycolipidLipid raftChemistrySialic acidRaftFluorescenceMembraneMoleculeBiochemistryBiophysicsBiologyOrganic chemistryPolymerPhysicsCopolymerQuantum mechanicsGlycosylation and Glycoproteins ResearchLipid Membrane Structure and BehaviorSphingolipid Metabolism and Signaling