Visible‐Light‐Induced Domino Cyclization to Access Pyrido[2,3‐<i>d</i>]pyrimidine‐2,4‐diones <i>via</i> a Radical‐Polar Crossover Reaction
Wanqing Zuo, Yu Cheng, Zhizhen Zhu, Lingling Zuo, Xiao Geng, Zhifang Li, Lei Wang
Abstract
Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now report a radical‐polar crossover (RPC)‐enabled three‐component cyclization of bromodifluoroalkyls with enaminones and 6‐aminouraciles via a visible‐light‐induced domino cyclization. The reaction exhibited a broad substrate scope (> 40 examples) including complex molecules, which highlighted the utility of this strategy for the construction of a library of bioactive analogs.
Topics & Concepts
ChemistryDominoPyrimidinePolarPhotochemistryVisible spectrumCrossoverRadical cyclizationCascade reactionStereochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisOptoelectronicsComputer scienceArtificial intelligenceAstronomyPhysicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions