Oxidative damage and delayed replication allow viable <i>Mycobacterium tuberculosis</i> to go undetected
Kohta Saito, Saurabh Mishra, Thulasi Warrier, Nico Cicchetti, Jianjie Mi, Elaina Weber, Xiuju Jiang, Julia Roberts, Alexandre Gouzy, Ellen Kaplan, Christopher D. Brown, Ben Gold, Carl Nathan
Abstract
and its derivative, BCG, fail to enter the DD state under similar conditions. These findings have implications for tuberculosis latency, detection, relapse, treatment monitoring, and development of regimens that overcome phenotypic antimicrobial resistance.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisMicrobiologyBiologyMultidrug tolerancePhenotypeAntibiotic resistanceViable but nonculturableVirologyBacteriaAntibioticsBiofilmMedicineGeneticsGenePathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisImmune responses and vaccinations