Investigation of the influence of chirality and halogen atoms on the anticancer activity of enantiopure palladium(<scp>ii</scp>) complexes derived from chiral amino-alcohol Schiff bases and 2-picolylamine
Hadi Amiri Rudbari, Nazanin Kordestani, José V. Cuevas, Min Zhou, Thomas Efferth, Isabel Correia, Tanja Schirmeister, Fabian Barthels, Mohammed Enamullah, Alexandra R. Fernandes, Nicola Micale
Abstract
In order to evaluate the impact of chirality and halogen-substitution pattern on biological activity, four mixed-ligand enantiomeric pairs of Pd( ii ) complexes were synthesized and characterized.
Topics & Concepts
ChemistryEnantiopure drugChirality (physics)PalladiumHalogenAlcoholStereochemistryMedicinal chemistryOrganic chemistryEnantioselective synthesisCatalysisNambu–Jona-Lasinio modelPhysicsAlkylChiral symmetry breakingQuantum mechanicsQuarkMetal complexes synthesis and propertiesCrystal structures of chemical compoundsCrystallography and molecular interactions