Microporous Annealed Particle (MAP) Scaffold Pore Size Influences Mesenchymal Stem Cell Metabolism and Proliferation Without Changing CD73, CD90, and CD105 Expression Over Two Weeks
Blaise N. Pfaff, Clare C. Flanagan, Donald R. Griffin
Abstract
Scaffold pore architecture is shown to influence stem cell fate through various avenues. It is demonstrated that microporous annealed particle (MAP) microgel diameter can be tuned to control scaffold pore size and, in turn, modulate mesenchymal stem cell (MSC) survivability, proliferation, metabolism, and migration, thereby enhancing bioactivity and guiding future applications of MAP for regenerative medicine.
Topics & Concepts
Mesenchymal stem cellScaffoldMicroporous materialCD90Cell biologyStem cellChemistryCell growthRegenerative medicineBiophysicsBiomedical engineeringMaterials scienceBiologyBiochemistryMedicineOrganic chemistryCD34Graphene and Nanomaterials ApplicationsElectrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative Medicine