Discovery of a triphenylamine-based ligand that targets mitochondrial DNA G-quadruplexes and activates the cGAS-STING immunomodulatory pathway
Xiaodong Wang, Yong-Si Liu, Mengdie Chen, Ming-Hao Hu
Topics & Concepts
Mitochondrial DNAMitochondrionChemistryStimulator of interferon genesCytosolCell biologyDNA damageLigand (biochemistry)StingDNACancer researchBiologyGeneBiochemistryReceptorEngineeringAerospace engineeringEnzymeinterferon and immune responsesRNA modifications and cancerRNA and protein synthesis mechanisms