Continuous flow synthesis of the URAT1 inhibitor lesinurad
Mariana C. F. C. B. Damião, Henrique Magri Marçon, Julio Cezar Pastre
Abstract
A 5-steps continuous flow synthesis of lesinurad is provided and delivers this API in 68% overall yield.
Topics & Concepts
Continuous flowYield (engineering)Flow (mathematics)Computer scienceEngineeringPhysicsMechanicsBiochemical engineeringThermodynamicsInnovative Microfluidic and Catalytic Techniques InnovationChemical Synthesis and AnalysisReceptor Mechanisms and Signaling