Inhibin β-A (INHBA) induces epithelial–mesenchymal transition and accelerates the motility of breast cancer cells by activating the TGF-β signaling pathway
Yingying Yu, Weiwei Wang, Wenying Lu, Wei Chen, Anquan Shang
Abstract
study showed that INHBA played an indispensable role in promoting BC cell proliferation and invasion. Mechanistically, INHBA induced epithelial-mesenchymal transition (EMT) and accelerated the motility of BC cells by activating TGF-β-regulated genes. In conclusion, INHBA plays a functional role in supporting EMT phenotype of BC cells, and it may serve as a diagnostic biomarker and a potential therapeutic target for BC treatment.
Topics & Concepts
Epithelial–mesenchymal transitionGene silencingOncogeneMotilityCancer researchBiologyDownregulation and upregulationCancerCell cycleCell biologyMetastasisGeneGeneticsTGF-β signaling in diseasesCancer Cells and MetastasisBiomarkers in Disease Mechanisms