Downregulation of hERG channel expression by tyrosine kinase inhibitors nilotinib and vandetanib predominantly contributes to arrhythmogenesis
Xiaoyan Cui, Jinglei Sun, Congxin Li, Suhua Qiu, Chenxia Shi, Jingtao Ma, Yanfang Xu
Topics & Concepts
VandetanibhERGNilotinibPharmacologyTyrosine kinaseTyrosine-kinase inhibitorDownregulation and upregulationChemistryMedicineInternal medicinePotassium channelBiochemistryCancerReceptorGeneCardiac electrophysiology and arrhythmiasIon channel regulation and functionCardiac Fibrosis and Remodeling