Hypoxia-Adapted Sono-chemodynamic Treatment of Orthotopic Pancreatic Carcinoma Using Copper Metal–Organic Frameworks Loaded with an Ultrasound-Induced Free Radical Initiator
Yu Sun, Jing Cao, Xue Wang, Cong Zhang, Jiali Luo, Yiqing Zeng, Chao Zhang, Qunying Li, Ying Zhang, Wen Xu, Tao Zhang, Pintong Huang
Abstract
OH) for chemodynamic therapy. When exposed to ultrasound irradiation, AIPH further degraded in an oxygen-independent manner to yield nitrogen bubbles and alkyl radicals, the former of which enhanced the ability of these nanoparticles to penetrate deeply into the tumor. The resultant radicals induced substantial DNA damage and apoptotic cell death within target tumors under different levels of oxygen availability. As such, this hypoxic TME-responsive synergistic sono-chemodynamic approach offers an ideal means of achieving oxygen-independent free radical generation and enhanced treatment efficacy.
Topics & Concepts
Sonodynamic therapyRadicalReactive oxygen speciesHydroxyl radicalTumor microenvironmentTumor hypoxiaMetal-organic frameworkCancer researchHypoxia (environmental)OxygenBiophysicsApoptosisChemistryMaterials scienceRadiation therapyBiochemistryMedicineOrganic chemistryBiologySurgeryAdsorptionTumor cellsNanoplatforms for cancer theranosticsMetal-Organic Frameworks: Synthesis and ApplicationsHeme Oxygenase-1 and Carbon Monoxide