<i>p</i>-Coumaric acid has pure anti-inflammatory characteristics against hepatopathy caused by ischemia-reperfusion in the liver and dust exposure.
Mojtaba Moradi, Yaghoob Farbood, Seyyed Ali Mard, Mahin Dianat, Gholamreza Goudarzi, Layasadat Khorsandi, Seyed Saeed Seyedian
Abstract
Objectives: -CA on liver damage induced by dust and IR injury in adult male rats. Materials and Methods: -CA, and dust were administrated 3 days a week for 6 consecutive weeks. Animals were sacrificed, the blood samples were aspirated and the liver sections were prepared for biochemical and histopathological assessments. Results: <0.05), the results represented that dust and IR can potentially increase the levels of ALT, AST, direct and total bilirubin, triglyceride, and cholesterol in serum. Also, MDA, TNF-α , NF-κB . HMGB-1 and ATG-7 levels were increased in hepatocytes. Gene expression of Nrf2, HOX-1, IL-6, HOTAIR, and miR-34a showed an incremental trend in the liver tissue. Total antioxidant capacity (TAC) in hepatocytes was decreased following dust exposure and IR induction. Also, miR-20b-5p, MEG3, and SIRT1 in the liver were decreased in dust and dust+IR groups. Conclusion: -CA protected hepatic injury induced by dust and IR by inhibition of oxidative injury, inflammation, and autophagy.