Annulated carbamates are precursors for the ring contraction of the adamantane framework
Radim Hrdina, Oksana M. Holovko-Kamoshenkova, Ivana Cı́sařová, Filip Koucký, Oldřich Machalický
Abstract
We report a protocol for the one-pot two-step synthesis of noradamantane methylene amines. The first step is the triflic acid-promoted decarboxylation of adamantane carbamates, which causes rearrangement of the adamantane framework to form noradamantane iminium salts, which are reduced to amines in the second separate step.
Topics & Concepts
AdamantaneTriflic acidChemistryIminiumDecarboxylationMethyleneRing (chemistry)Combinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisEicosanoids and Hypertension PharmacologyCarbon dioxide utilization in catalysisOxidative Organic Chemistry Reactions