Repurposing of intestinal defensins as multi-target, dual-function amyloid inhibitors <i>via</i> cross-seeding
Yijing Tang, Dong Zhang, Xiong Gong, Jie Zheng
Abstract
Amyloid formation and microbial infection are the two common pathological causes of neurogenerative diseases. Here, we proposed a new “anti-amyloid and anti-bacteria” strategy to repurpose two intestinal defensins as multiple-target, dual-function amyloid inhibitors.
Topics & Concepts
RepurposingDual (grammatical number)Function (biology)Amyloid (mycology)SeedingDual functionChemistryBiologyComputer scienceCell biologyPhilosophyLinguisticsContouringInorganic chemistryComputer graphics (images)EcologyAgronomyAntimicrobial Peptides and ActivitiesProtein Hydrolysis and Bioactive PeptidesBiochemical and Structural Characterization