The impact of functional delayed graft function in the modern era of kidney transplantation – A retrospective study
Enrique Montagud‐Marrahí, Alícia Molina‐Andújar, Jordi Rovira, Ignacio Revuelta, Pedro Ventura‐Aguiar, Gastón Piñeiro, Jessica Ugalde, Francesco Perna, José‐Vicente Torregrosa, Federico Oppenheimer, Núria Esforzado, Frederic Cofán, Josep M. Campistol, Adriana Herrera‐Garcia, José Ríos, Fritz Diekmann, David Cucchiari
Abstract
as a surrogate end-point for graft failure. Secondary outcome was a composite outcome that included graft failure as above and also patient's death. Median follow-up was 3.22 [2.38-4.21] years. Seventy-nine patients developed dDGF (31.2%) and 127 developed fDGF (50.2%). Sixty-three patients fulfilled criteria for both definitions (24.9%). At multivariable analysis, the two definitions were significantly associated with the primary [HR (95%CI) 2.07 (1.09-3.94), P = 0.026 for fDGF and HR (95%CI) 2.41 (1.33-4.37), P = 0.004 for dDGF] and the secondary composite outcome [HR (95%CI) 1.58 (1.01-2.51), P = 0.047 for fDGF and HR (95%CI) 1.67 (1.05-2.66), P = 0.028 for dDGF]. Patients who met criteria for both definitions had the worst prognosis, with a three-year estimates (95%CI) of survival from the primary and secondary outcomes of 2.31 (2.02-2.59) and 2.20 (1.91-2.49) years for fDGF+/dDGF+, in comparison with the other groups (P < 0.01 for trend). fDGF provides supplementary information about graft outcomes on top of the dDGF definition in a modern series of kidney transplantation.