A computational perspective on the dynamic behaviour of recurrent drug resistance mutations in the pncA gene from <i>Mycobacterium tuberculosis</i>
Taimoor Ashraf Khan, Abbas Khan, Syed Shujait Ali, Shahid Ali, Dong‐Qing Wei
Abstract
and PZA. In the G97D mutant, reported as most lethal, mutation causes the binding pocket to change considerably, so that the position of PZA has a large movement in the binding pocket. In this study, the resistance mechanism of PZA at the atomic level is proposed. The proposed drug-resistance mechanism will provide valuable guidance for the design of anti-tuberculosis drugs.
Topics & Concepts
Mycobacterium tuberculosisDrug resistanceGeneGeneticsTuberculosisBiologyComputational biologyMicrobiologyVirologyMedicinePathologyTuberculosis Research and EpidemiologyProtein Structure and DynamicsRNA and protein synthesis mechanisms