The development and function of human monocyte-derived dendritic cells regulated by metabolic reprogramming
Ying Zhao, Cuie Gao, Lu Liu, Li Wang, Zhiqiang Song
Abstract
Human monocyte-derived dendritic cells (moDCs) that develop from monocytes play a key role in innate inflammatory responses as well as T cell priming. Steady-state moDCs regulate immunogenicity and tolerogenicity by changing metabolic patterns to participate in the body's immune response. Increased glycolytic metabolism after danger signal induction may strengthen moDC immunogenicity, whereas high levels of mitochondrial oxidative phosphorylation were associated with the immaturity and tolerogenicity of moDCs. In this review, we discuss what is currently known about differential metabolic reprogramming of human moDC development and distinct functional properties.
Topics & Concepts
BiologyImmunogenicityCell biologyDendritic cellMonocyteOxidative phosphorylationImmune systemReprogrammingFunction (biology)Innate immune systemPriming (agriculture)ImmunologyCellBiochemistryBotanyGerminationImmune cells in cancerImmunotherapy and Immune ResponsesImmune Cell Function and Interaction