Glomerular Disease in Temporal Association with SARS-CoV-2 Vaccination: A Series of 29 Cases
Caza, Tiffany N, Cassol, Clarissa A, Messias, Nidia, Hannoudi, Andrew, Haun, Randy S, Walker, Patrick D, May, Rebecca M, Seipp, Regan M, Betchick, Elizabeth J, Amin, Hassan, Ziadie, Mandolin S, Haderlie, Michael, Eduwu-Okwuwa, Joy, Vancea, Irina, Seek, Melvin, Elashi, Essam B, Shenoy, Ganesh, Khalillullah, Sayeed, Flaxenburg, Jesse A, Brandt, John, Diamond, Matthew J, Frome, Adam, Kim, Eugene H, Schlessinger, Gregory, Ulozas, Erlandas, Weatherspoon, Janice L, Hoerschgen, Ethan Thomas, Fabian, Steven L, Bae, Sung Yong, Iqbal, Bilal, Chouhan, Kanwalijit K, Karam, Zeina, Henry, James T, Larsen, Christopher P
Abstract
Background: Immune responses to vaccination are a known trigger for a new onset of glomerular disease or disease flare in susceptible individuals. Mass immunization against SARS-CoV-2 in the COVID-19 pandemic provides a unique opportunity to study vaccination-associated autoimmune kidney diseases. In the recent literature, there are several patient reports demonstrating a temporal association of SARS-CoV-2 immunization and kidney diseases.\nMethods: Here, we present a series of 29 cases of biopsy-proven glomerular disease in patients recently vaccinated against SARS-CoV-2 and identified patients who developed a new onset of IgA nephropathy, minimal change disease, membranous nephropathy, ANCA-associated GN, collapsing glomerulopathy, or diffuse lupus nephritis diagnosed on kidney biopsies postimmunization, as well as recurrent ANCA-associated GN. This included 28 cases of\nResults: The patients with collapsing glomerulopathy were of Black descent and had two\nConclusions: Glomerular disease to vaccination is rare, although it should be monitored as a potential adverse event.