Advances in pyrazolo[1,5-<i>a</i>]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment
Terungwa H. Iorkula, Osasere Jude-Kelly Osayawe, Daniel A. Odogwu, Latifat Oluwatobi Ganiyu, Emmanuel Faderin, Raymond Femi Awoyemi, Busayo Odunayo Akodu, Ikhazuagbe H. Ifijen, Omowunmi Rebecca Aworinde, Peter Agyemang, Odo Lovelyn Onyinyechi
Abstract
studies, have demonstrated their cytotoxicity, kinase selectivity, and antiproliferative effects. Despite these advances, challenges such as drug resistance, off-target effects, and toxicity persist. Future research will focus on optimizing synthetic approaches, improving drug selectivity, and enhancing bioavailability to increase clinical efficacy.
Topics & Concepts
Protein kinase AKinaseChemistryCancerCancer researchPharmacologyBiochemistryCombinatorial chemistryBiologyGeneticsQuinazolinone synthesis and applicationsSynthesis and biological activitySynthesis and Reactivity of Heterocycles