Electrochemical Hofmann rearrangement at high current densities in a simple flow setup
Darryl F. Nater, P. Hendriks, Siegfried R. Waldvogel
Abstract
A reliable electrochemical version for the Hofmann rearrangement has been established, which can be performed at high current density in simple, commercial flow electrolysis cells. The protocols have been optimized towards both aromatic and aliphatic substrates, yielding good to excellent yields across a broad substrate scope. The method can also easily be performed at multi-gram scale.
Topics & Concepts
ElectrolysisElectrochemistrySubstrate (aquarium)Simple (philosophy)Current (fluid)Flow (mathematics)Current densityScope (computer science)CatalysisChemistryScale (ratio)Combinatorial chemistryMaterials scienceProcess engineeringNanotechnologyChemical engineeringComputer scienceElectrodeMechanicsOrganic chemistryPhysicsThermodynamicsPhysical chemistryEngineeringGeologyQuantum mechanicsElectrolytePhilosophyOceanographyProgramming languageEpistemologyElectrocatalysts for Energy ConversionCO2 Reduction Techniques and CatalystsRadical Photochemical Reactions