Synthesis of triazole bridged <i>N</i>-glycosides of pyrazolo[1,5-<i>a</i>]pyrimidinones as anticancer agents and their <i>in silico</i> docking studies
Ghanshyam Tiwari, Vinay Kumar Mishra, Priti Kumari, Ashish Khanna, Sunil Sharma, Ram Sagar
Abstract
An efficient microwave assisted synthesis of diverse triazole bridged N -glycosides of pyrazolo[1,5- a ]pyrimidinones as new glycohybrids has been developed. The anti-cancer property of these glycohybrids was evaluated against MCF-7, MDA-MB231 and MDA-MB453 cell lines.
Topics & Concepts
PyrimidinonesChemistryTriazoleGlycosideStereochemistryIn silicoDocking (animal)Combinatorial chemistry1,2,4-TriazoleOrganic chemistryBiochemistryMedicineGeneNursingSynthesis and biological activitySynthesis and Biological EvaluationCarbohydrate Chemistry and Synthesis