Development of sulfonamide-based NLRP3 inhibitors: Further modifications and optimization through structure-activity relationship studies
Yiming Xu, Yulong Xu, Hallie Blevins, Chunqing Guo, Savannah Biby, Xiang‐Yang Wang, Changning Wang, Shijun Zhang
Topics & Concepts
ChemistrySulfonamideLead compoundIn vivoMoietyStructure–activity relationshipSmall moleculeInflammasomeDocking (animal)Combinatorial chemistryPharmacologyComputational biologyBiochemistryIn vitroStereochemistryReceptorMedicineBiologyNursingBiotechnologyInflammasome and immune disordersSphingolipid Metabolism and SignalingCholesterol and Lipid Metabolism