Dual STING activation and CD47/SIRPα blockade via chitooligosaccharide-based nanoparticles to amplify antitumor immunity
Shaohui Xu, Jiahan Shao, Zhijun Miao, Heng Wang, Huaxing Dai, Bo Tian, Run Shi, Yinan Zhong, Chao Wang
Topics & Concepts
StingChemistryTLR7CXCL10Tumor microenvironmentStimulator of interferon genesCancer researchInnate immune systemImmune systemCancer immunotherapyNanomedicineInterferonChemokineBlockadeMacrophageSignal transductionImmunotherapyDendritic cellPharmacologyImmunogenic cell deathPhagocytosisAcquired immune systemCancer cellTLR3ImmunosurveillanceImmunityCell cycle checkpointCell biologyCellReceptorMonocyteinterferon and immune responsesPhagocytosis and Immune RegulationInflammation biomarkers and pathways