Structure–Activity Relationship of USP5 Inhibitors
Mandeep Mann, Carlos Zepeda‐Velázquez, Héctor González-Álvarez, Aiping Dong, Taira Kiyota, Asma M. Aman, P. Loppnau, Yanjun Li, Brian J. Wilson, C.H. Arrowsmith, Rima Al‐awar, Rachel Harding, Matthieu Schapira
Abstract
assay. This study provides a chemical and structural framework for the discovery of a chemical probe to delineate USP5 function in cells.
Topics & Concepts
UbiquitinChemistryDeubiquitinating enzymeStructure–activity relationshipIn vitroZinc fingerBiochemistryCell biologyStereochemistryComputational biologyGeneBiologyTranscription factorUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism