Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity
Pengchong Li, Mengdi Jiang, Ketian Li, Hao Li, Yangzhong Zhou, Xinyue Xiao, Yue Xu, Suzanne Krishfield, Peter E. Lipsky, George C. Tsokos, Xuan Zhang
Topics & Concepts
GPX4ImmunologyAutoimmunitySystemic lupus erythematosusAutoantibodyNeutrophil extracellular trapsPathogenesisBiologyMedicineGlutathione peroxidaseAntibodyDiseaseOxidative stressInflammationSuperoxide dismutaseInternal medicineNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammasome and immune disordersinterferon and immune responses